Contraindicated (one)pentobarbital will lower the level or outcome of cariprazine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is answerable for the formation and elimination of cariprazine's Energetic metabolites.pentobarbital and olopatadine intranasal each boost sedation. Avoid or Use Alternate Drug. Coadmini